Dual-transmitter systems regulating arousal, attention, learning and memory

S Ma; B Hangya; CS Leonard; W Wisden; AL Gundlach

Journal article

Dual-transmitter systems regulating arousal, attention, learning and memory

S Ma, B Hangya, CS Leonard, W Wisden, AL Gundlach

Neuroscience and Biobehavioral Reviews | Published : 2018

DOI: 10.1016/j.neubiorev.2017.07.009

Abstract

An array of neuromodulators, including monoamines and neuropeptides, regulate most behavioural and physiological traits. In the past decade, dramatic progress has been made in mapping neuromodulatory circuits, in analysing circuit dynamics, and interrogating circuit function using pharmacogenetic, optogenetic and imaging methods This review will focus on several distinct neural networks (acetylcholine/GABA/glutamate; histamine/GABA; orexin/glutamate; and relaxin-3/GABA) that originate from neural hubs that regulate wakefulness and related attentional and cognitive processes, and highlight approaches that have identified dual transmitter roles in these behavioural functions. Modulation of the..

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University of Melbourne Researchers

Andrew Gundlach Author

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Grants

Awarded by National Institute of Neurological Disorders and Stroke

Funding Acknowledgements

We thank Katalin Sviatko for help with the figures. SM was supported by a National Health and Medical Research Council of Australia project grant (1067522). BH was supported by the 'Lendulet' Program of the Hungarian Academy of Sciences (LP2015-2/2015) and he is a member of the FENS-Kavli Network of Excellence. CSL was funded by PHS grant NS027881. WW holds a joint Wellcome Trust Investigator Award (together with Nicholas P Franks; 107841/Z/15/Z). ALG was supported by a National Health and Medical Research Council of Australia Research Fellowship (1005985) and project grant (1067522), and a Brain&Behavior Research Foundation (USA) NARSAD Independent Investigator Award.